Antihistamines, especially sedating ones, have the ability to cross the blood-brain barrier and tend to cause more adverse reactions than ‘second generation’ or ‘non-sedating’ antihistamines.

The most common adverse effects with sedating antihistamines are sedation, dizziness and incoordination. However, paradoxical stimulation ranging from excitation through to tremors, hallucinations and convulsions may occur. Excessive doses in children have led to respiratory depression and very critical condition.

With winter approaching, it is important to note that coughs and colds are often self-limiting conditions and may not require pharmacological intervention. Antihistamines (especially in less than 2 year olds) may lead to dryness of secretions which can lead to extreme discomfort and respiratory difficulty. It can lead to worsening of symptoms.
Symptomatic measures, such as increasing fluids, making sure children get enough rest and reducing the spread of the virus (including regular hand washing) should be practiced.