Pediatric procedural sedation (PPS) given intravenously refers to techniques and medications used to minimize anxiety and pain associated with unpleasant or painful procedures. PPS is used when painful or uncomfortable procedures are unavoidable and incorporates physical, psychological, and pharmacologic interventions to minimize discomfort. In the pediatric population, PPS is not limited to major painful procedures requiring deeper levels of sedation. Common procedures, such as IV cannulation, venipuncture, urethral catheterization, and lumbar puncture, can be associated with significant distress or pain in pediatric patients. Many pediatric patients may require anxiolysis to have CT or MRI imaging, ultrasound, or echocardiography to ensure adequate imaging is obtained and minimize patient stress.